26S proteasome non-ATPase regulatory subunit 10 or gankyrin is an enzyme that in humans is encoded by the PSMD10 gene. First isolated in 1998 by Tanaka et al.; Gankyrin is an oncoprotein that is a component of the 19S regulatory cap of the proteasome. Structurally, it contains a 33-amino acid ankyrin repeat that forms a series of alpha helices. It plays a key role in regulating the cell cycle via protein-protein interactions with the cyclin-dependent kinase CDK4. It also binds closely to the E3 ubiquitin ligase MDM2, which is a regulator of the degradation of p53 and retinoblastoma protein, both transcription factors involved in tumor suppression and found mutated in many cancers. Gankyrin also has an anti-apoptotic effect and is overexpressed in certain types of tumor cells such as hepatocellular carcinoma.
"}{"type":"standard","title":"Hoffmannseggia microphylla","displaytitle":"Hoffmannseggia microphylla","namespace":{"id":0,"text":""},"wikibase_item":"Q5876720","titles":{"canonical":"Hoffmannseggia_microphylla","normalized":"Hoffmannseggia microphylla","display":"Hoffmannseggia microphylla"},"pageid":20762503,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/a/ac/Hoffmannseggia_microphylla.jpg/330px-Hoffmannseggia_microphylla.jpg","width":320,"height":213},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/a/ac/Hoffmannseggia_microphylla.jpg","width":1280,"height":853},"lang":"en","dir":"ltr","revision":"1173366496","tid":"77f1a2da-4925-11ee-a9d5-e24c1270e0cd","timestamp":"2023-09-02T00:12:57Z","description":"Species of legume","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Hoffmannseggia_microphylla","revisions":"https://en.wikipedia.org/wiki/Hoffmannseggia_microphylla?action=history","edit":"https://en.wikipedia.org/wiki/Hoffmannseggia_microphylla?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Hoffmannseggia_microphylla"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Hoffmannseggia_microphylla","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Hoffmannseggia_microphylla","edit":"https://en.m.wikipedia.org/wiki/Hoffmannseggia_microphylla?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Hoffmannseggia_microphylla"}},"extract":"Hoffmannseggia microphylla is a species of flowering plant in the legume family known by the common name wand holdback. It is native to the southwestern United States and Baja California and grows in gullies, canyons, slopes and primarily creosote bush scrub.","extract_html":"
Hoffmannseggia microphylla is a species of flowering plant in the legume family known by the common name wand holdback. It is native to the southwestern United States and Baja California and grows in gullies, canyons, slopes and primarily creosote bush scrub.
"}{"type":"standard","title":"Tony Angell","displaytitle":"Tony Angell","namespace":{"id":0,"text":""},"wikibase_item":"Q7821763","titles":{"canonical":"Tony_Angell","normalized":"Tony Angell","display":"Tony Angell"},"pageid":26085416,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/5/54/Tony_Angell.JPG/330px-Tony_Angell.JPG","width":320,"height":481},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/5/54/Tony_Angell.JPG","width":1288,"height":1936},"lang":"en","dir":"ltr","revision":"1257085236","tid":"b152aa80-a175-11ef-b619-c12b27ae5d06","timestamp":"2024-11-13T04:13:53Z","description":"American wildlife artist, environmental educator, and writer","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Tony_Angell","revisions":"https://en.wikipedia.org/wiki/Tony_Angell?action=history","edit":"https://en.wikipedia.org/wiki/Tony_Angell?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Tony_Angell"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Tony_Angell","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Tony_Angell","edit":"https://en.m.wikipedia.org/wiki/Tony_Angell?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Tony_Angell"}},"extract":"Tony Angell is an American wildlife artist, environmental educator, and writer. He has lived in Seattle, Washington, since 1959.","extract_html":"
Tony Angell is an American wildlife artist, environmental educator, and writer. He has lived in Seattle, Washington, since 1959.
"}{"slip": { "id": 63, "advice": "If you're squashed close to strangers on public transport, try not to be rude to them. No one likes those situations."}}
{"fact":"Not every cat gets \\high\\\" from catnip. Whether or not a cat responds to it depends upon a recessive gene: no gene\"","length":115}
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